Gassan_GoodBye_50_JoeJoseph M. Lasker, Ph.D.
212 854 5738 (office) or 212 342 0086 (lab)
jml2012@columbia.edu

I am overseeing the developement of a new digital optical imager. Our previous instrumentation uses analog detection techniques and industry-standard data acquisition boards to collect light measurements from a target medium. They are therfore subject to the inherent noises and limitations of analog electronics. To improve instrument performance and to offer greater flexibility, we are designing an new imager that employs an integrated Digital Signal Processor at its core. Our goal is to realize a versatile, compact, high-precision optical-measurement system that facilitates real-time dynamic imaging. Once Instrument is complete, we will use it to investigate patients afflicted with Rehumatoid Arthritis. We hope to distiguish functional characteristics between healthy joints and those infected by RA, and quantify those differences as a measure of the disease progression.

Publications:
  1. J.M. Lasker, J. Masciotti, C.H. Schmitz, R.L. Barbour, A. H. Hielscher, "A digital signal processor-based detection system for Optical Tomography," OSA Biomedical Topical Meetings, Advances in optical Imaging and Photon Migration (Miami Beach, FL, April 14-17, 2004)
  2. J. M. Lasker, A. Y. Bluestone, C. H. Schmitz, R. L. Barbour, A. H. Hielscher, "Three-dimensional optical-tomographic dynamic imaging of small tissue volumes," OSA Biomedical Topical Meetings, Advances in Optical Imaging and Photon Migration (Miami Beach, FL, April 7-10, 2002)
  3. C. H. Schmitz, Y. Pei, H. L. Graber, J. M. Lasker, A. H. Hielscher, R. L. Barbour, "Instrumentation for Real-Time Dynamic Optical Tomography," in Photon Migration, Optical Coherence Tomography, and Microscopy (Proceedings of SPIE, Vol. 4431), Stefan Andersson-Engels, Michael Kaschke, Eds., pp. 282-291 (2001).
  4. C. H. Schmitz, M. Löcker, J. Lasker, A. H. Hielscher, R. L. Barbour, "Performance characteristics of a silicon diode (SiPD) based instrument for fast functional optical tomography," in Optical Tomography and Spectroscopy of Tissue IV (Proceedings of SPIE, Vol. 4250), B. Chance, R. R. Alfano, B. J. Tromberg, M. Tamura, E. M. Sevick-Muraca, Eds., pp. 171-179 (2001).
  5. C. H. Schmitz, M. Löcker, J. M. Lasker, A. H. Hielscher, R. L. Barbour, "Instrumentation for fast functional optical tomography," Review of Scientific Instruments, Vol. 73, pp. 429-439 (2002).

 
 
 
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